This is the follow up paper to the clinical trial done by Dr. Eissenberg on the electronic cigarette. This new research article was completed by Andrea R Vansickel, Caroline O. Cobb, Michael, F. Weaver, and Thomas E. Eissenberg. They evaluated the electronic cigarette for the amount of nicotine it delivered (16 to 18 mg/ml cartridges were used), for the amount of carbon monoxide it delivered, and for how well it suppressed the urge to smoke tobacco cigarettes.

Here is what they found:

“The results of this study show the usefulness of the clinical model and suggest that, unlike puffing from a tobacco cigarette, two 10-puff bouts with the two electronic cigarettes described here expose users to no measurable nicotine or CO and do not increase heartrate. Despite the failure to deliver nicotine, acute use ofthe two products tested in this study produced some tobacco abstinence symptom suppression and increased subjective ratings of acceptability.”

We knew that electronic cigarettes weren’t going to test positive for carbon monoxide, since that is a byproduct of burning, not vaporizing. And many e-smokers knew that the electronic cigarette was acceptable to them as an alternative to their tobacco cigarettes. But what about delivering no nicotine? Well in this study they took smokers who had never used an electronic cigarette before and had them take 10 puffs and measured their nicotine blood plasma level. Any veteran vaper will immediately point out that using an electronic cigarette does have a learning curve and that there are many different models and different e-liquids on the market. These factors, although with varied individual usage, will have an effect on the results. This was addressed in the paper as such:

“The results of some outcome measures might be influenced by longer-term use, different puffing profiles, other electronic cigarette models/cartridge strengths, and/or the user’s previous experience with electronic cigarettes.”

What is interesting is that even with new electronic cigarette users only taking 10 puffs at a time and not getting any measurable nicotine into their system; they still found the electronic cigarette to be a good alternative to tobacco cigarettes.

“In spite of delivering no measurable nicotine, both electronic cigarettes tested in this study reduced ratings of “craving a cigarette” and “urge to smoke” and increased subjective ratings of product acceptability (e.g., “satisfying,” “taste good,” “pleasant”). These results are consistent with anecdotal reports from long-term electronic cigarette users and support the notion that electronic cigarettes may provide an alternative, perhaps a substitute, to cigarette smoking in some cases.”

If you would like to read the full article, visit A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects or visit for an abstract.

One thought on “A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects

  1. I started used the e cigs. two mo ago. I have been able to quit conventional cigaretts .The standard smokes would leave me feeling ill after the first couple in the morning .
    The e cigs. have raised my energy level and I feel better than I have in years ! I smoked 1 1/2 packs a day . I am 60 yrs. old and have beginings of COPD . The e cig. is a godsend for me . My wife cna rest assured I have finally quit !

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